AGEs and Atherosclerosis
نویسنده
چکیده
Atherogenesis comprises three stages, including intimal thickening, plaque formation and destabilization and rupture of the plaque. Intimal thickening develops depending upon aging and is characterized by increased collagenous matrix. Plaque formation is characterized by an accumulation of intraand extracelluar lipids in intima, resulting in the advanced lesion with atheroma. Finally, advanced lesion is destablilized by plaque inflammation,and subsequently ruptures, leading to clinical manifestations. AGEs include various chemical structures, such as(carboxymethyl) lysine,(carboxymethyl) arginine and pyrraline. Different AGEs are derived from different pathways, which are oxidation-dependent or oxidation-independent. In this paper, the role of various AGEs in different stages of atherogenesisi is described.
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